Bone augmentation of the atrophic anterior maxilla for dental implants using rhBMP-2 and titanium mesh: histological and tomographic analysis.
Identifieur interne : 001370 ( Main/Exploration ); précédent : 001369; suivant : 001371Bone augmentation of the atrophic anterior maxilla for dental implants using rhBMP-2 and titanium mesh: histological and tomographic analysis.
Auteurs : S A Ribeiro Filho [Brésil] ; C E Francischone [Brésil] ; J C De Oliveira [Brésil] ; L Z Ribeiro [Brésil] ; F Z X. Do Prado [Brésil] ; B S Sotto-Maior [Brésil]Source :
- International journal of oral and maxillofacial surgery [ 1399-0020 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Atrophie, Biopsie, Facteur de croissance transformant bêta (usage thérapeutique), Femelle, Filet chirurgical, Humains, Implants dentaires, Lambeaux chirurgicaux, Maxillaire (), Maxillaire (imagerie diagnostique), Mâchoire partiellement édentée (imagerie diagnostique), Mâchoire partiellement édentée (rééducation et réadaptation), Mâle, Ostéotomie, Pose d'implant dentaire endo-osseux, Protéine morphogénétique osseuse de type 2 (usage thérapeutique), Protéines recombinantes (usage thérapeutique), Reconstruction de crête alvéolaire (), Résultat thérapeutique, Titane, Tomodensitométrie à faisceau conique, Études prospectives.
- MESH :
- imagerie diagnostique : Maxillaire, Mâchoire partiellement édentée.
- rééducation et réadaptation : Mâchoire partiellement édentée.
- usage thérapeutique : Facteur de croissance transformant bêta, Protéine morphogénétique osseuse de type 2, Protéines recombinantes.
- Adulte d'âge moyen, Atrophie, Biopsie, Femelle, Filet chirurgical, Humains, Implants dentaires, Lambeaux chirurgicaux, Maxillaire, Mâle, Ostéotomie, Pose d'implant dentaire endo-osseux, Reconstruction de crête alvéolaire, Résultat thérapeutique, Titane, Tomodensitométrie à faisceau conique, Études prospectives.
English descriptors
- KwdEn :
- Alveolar Ridge Augmentation (methods), Atrophy, Biopsy, Bone Morphogenetic Protein 2 (therapeutic use), Cone-Beam Computed Tomography, Dental Implantation, Endosseous, Dental Implants, Female, Humans, Jaw, Edentulous, Partially (diagnostic imaging), Jaw, Edentulous, Partially (rehabilitation), Male, Maxilla (diagnostic imaging), Maxilla (surgery), Middle Aged, Osteotomy, Prospective Studies, Recombinant Proteins (therapeutic use), Surgical Flaps, Surgical Mesh, Titanium, Transforming Growth Factor beta (therapeutic use), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Bone Morphogenetic Protein 2, Recombinant Proteins, Transforming Growth Factor beta.
- diagnostic imaging : Jaw, Edentulous, Partially, Maxilla.
- methods : Alveolar Ridge Augmentation.
- rehabilitation : Jaw, Edentulous, Partially.
- surgery : Maxilla.
- Atrophy, Biopsy, Cone-Beam Computed Tomography, Dental Implantation, Endosseous, Dental Implants, Female, Humans, Male, Middle Aged, Osteotomy, Prospective Studies, Surgical Flaps, Surgical Mesh, Titanium, Treatment Outcome.
Abstract
The loss of multiple teeth or trauma to the anterior maxilla often results in a deficient ridge width for prosthetic tooth rehabilitation. This study evaluated the use of titanium mesh and recombinant human bone morphogenetic protein 2 (rhBMP-2) for the repair of major bone defects in the alveolar bone. Five patients were enrolled in the study; these patients required implant replacements for two contiguous missing teeth in the anterior maxilla, which lacked sufficient bone. Residual ridges were augmented with rhBMP-2 and titanium mesh to direct the geometry of the newly formed bone. Seven months later, a bone biopsy specimen was removed from the implantation site before osteotomy and insertion of dental implants. Cone beam computed tomography (CBCT) scans were obtained preoperatively, postoperatively (baseline), and 48 months after implantation to evaluate implant healing. All dental implants were placed in the grafted sites without the need for further bone augmentation. The most frequent adverse effects were facial oedema and oral erythema. Biopsy specimens were used to evaluate bone quality. CBCT scans provided a prediction of alveolar restoration and long-term success. The combination of rhBMP-2 and titanium mesh provided effective augmentation of the atrophic anterior maxilla prior to implant placement.
DOI: 10.1016/j.ijom.2015.07.004
PubMed: 26235628
Affiliations:
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This study evaluated the use of titanium mesh and recombinant human bone morphogenetic protein 2 (rhBMP-2) for the repair of major bone defects in the alveolar bone. Five patients were enrolled in the study; these patients required implant replacements for two contiguous missing teeth in the anterior maxilla, which lacked sufficient bone. Residual ridges were augmented with rhBMP-2 and titanium mesh to direct the geometry of the newly formed bone. Seven months later, a bone biopsy specimen was removed from the implantation site before osteotomy and insertion of dental implants. Cone beam computed tomography (CBCT) scans were obtained preoperatively, postoperatively (baseline), and 48 months after implantation to evaluate implant healing. All dental implants were placed in the grafted sites without the need for further bone augmentation. The most frequent adverse effects were facial oedema and oral erythema. Biopsy specimens were used to evaluate bone quality. CBCT scans provided a prediction of alveolar restoration and long-term success. The combination of rhBMP-2 and titanium mesh provided effective augmentation of the atrophic anterior maxilla prior to implant placement.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>District fédéral (Brésil)</li><li>Goiás</li><li>Minas Gerais</li><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><country name="Brésil"><region name="Goiás"><name sortKey="Ribeiro Filho, S A" sort="Ribeiro Filho, S A" uniqKey="Ribeiro Filho S" first="S A" last="Ribeiro Filho">S A Ribeiro Filho</name></region><name sortKey="De Oliveira, J C" sort="De Oliveira, J C" uniqKey="De Oliveira J" first="J C" last="De Oliveira">J C De Oliveira</name><name sortKey="Do Prado, F Z X" sort="Do Prado, F Z X" uniqKey="Do Prado F" first="F Z X" last="Do Prado">F Z X. Do Prado</name><name sortKey="Francischone, C E" sort="Francischone, C E" uniqKey="Francischone C" first="C E" last="Francischone">C E Francischone</name><name sortKey="Ribeiro, L Z" sort="Ribeiro, L Z" uniqKey="Ribeiro L" first="L Z" last="Ribeiro">L Z Ribeiro</name><name sortKey="Sotto Maior, B S" sort="Sotto Maior, B S" uniqKey="Sotto Maior B" first="B S" last="Sotto-Maior">B S Sotto-Maior</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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